Category Archives: Proof of Concept

Supplementation with gliadin-combined plant superoxide dismutase extracts promotes antioxidant defenses and protects against oxidative stress

I. Vouldoukis, M. Conti, P. Krauss, C. Kamate, S. Blazquez, M. Tefit, D. Mazier, A. Calenda, B. Dugas. “Supplementation with gliadin-combined plant superoxide dismutase extracts promotes antioxidant defenses and protects against oxidative stress,” Phytotherapy Res Mar 1;18(12) (2004) 957-962 PMID: 15742357.

(Click above for link to article.)

Wheat gliadine promotes the Interleukin-4 induced IgE production by normal human peripheral mononuclear cells through a redox dependent mechanism

B. Dugas, N. Dugas, M. Conti, A. Calenda, P. Pino, Y. Thomas, D. Mazier, I. Vouldoukis. “Wheat gliadine promotes the Interleukin-4 induced IgE production by normal human peripheral mononuclear cells through a redox dependent mechanism,” Cytokine 21, (2003) 1-11 PMID: 12824000.

(Click above for link to article.)

Recombinant Ochrobactrum anthropiexpressing Brucella abortus Cu, ZN superoxide dismutase protects mice against B. abortus infection only after switching of immune responses to Th1 type

Y. He, R. Vemulapalli, GG Schuring. “Recombinant Ochrobactrum anthropiexpressing Brucella abortus Cu, ZN superoxide dismutase protects mice against B. abortus infection only after switching of immune responses to Th1 type,” Infection and Immunity. (2002) May 70(5) 2535-43 PMID: 11953393.

(Click above for link to article.)

Fc-receptor-mediated intracellular delivery of Cu/Zn-superoxide dismutase (SOD1) protects against redox-induced apoptosis through a nitric oxide dependent mechanism

I. Vouldoukis, V. Sivan, M.C. Vozenin, C. Kamate, A. Calenda, D. Mazier, B. Dugas. “Fc-Receptor-Mediated Intracellular Delivery of CuZn-superoxide Dismutase Protects Against Redox-Induced Apoptosis,Molecular Medicine. (2000) 6 (12) 1042 PMID: 11474120.

(Click the title of the study for a link to the abstract, or download in PDF format.)