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Portfolio Archives: 2. Proof of concept

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Intestinal cell targeting of a stable recombinant Cu–Zn SOD from Cucumis melo fused to a gliadin peptide

2. Proof of concept, Scientific studiesBy glisodinadminMarch 10, 2012Leave a comment

We have shown that a gliadin peptide fused to Cu–Zn SOD allows it to physically interact with a potential receptor on the surface of pithelial cells without altering the antioxidant activity of the SOD protein.

supplementation with gliadin-combined standardized melon SOD extract (Glisodin) promoted the cellular antioxidant status and protected against oxidative stress-induced cell death.
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Supplementation with gliadin-combined plant superoxide dismutase extracts promotes antioxidant defenses and protects against oxidative stress

2. Proof of concept, 3. Antioxidant & AgingBy glisodinadminMarch 1, 2005Leave a comment

Supplementation with gliadin-combined standardized melon SOD extract (Glisodin) promoted the cellular antioxidant status and protected against oxidative stress-induced cell death.

Antioxidant and anti-inflammatory properties of a Cucumis melon extract rich in superoxide dismutase activity
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Antioxidant and anti-inflammatory properties of a Cucumis melon extract rich in superoxide dismutase activity

2. Proof of concept, Scientific studiesBy glisodinadminSeptember 4, 2004Leave a comment

The development of dietary delivery systems using wheat gliadin biopolymers; as a natural carrier represents a new alternative.

Induction of Th1-dependent immunity by an orally effective melon SOD extract
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Induction of Th1-dependent immunity by an orally effective melon SOD extract

2. Proof of concept, 4. Immune Modulation, Scientific studiesBy glisodinadminMay 1, 2003Leave a comment

In this study, we have shown that this combination also primed and polarized the mouse Th1/Th2 immune response by affecting: (a) the production of IFN-γ and IL-4 cytokines from primed spleen cells after stimulation with Con-A and (b) the isotypes of antibody response (IgG, IgE and IgA).

Wheat gliadin promotes the interleukin-4-induced IgE production by normal human peripheral mononuclear cells through a redox-dependent mechanism
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Wheat gliadin promotes the Interleukin-4 induced IgE production by normal human peripheral mononuclear cells through a redox dependent mechanism

2. Proof of concept, Scientific studiesBy glisodinadminMarch 21, 2003Leave a comment

The development of dietary delivery systems using wheat gliadin biopolymers; as a natural carrier represents a new alternative.

Fc-Receptor-Mediated Intracellular Delivery of CuZn-superoxide Dismutase Protects Against Redox-Induced Apoptosis
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Fc-Receptor-Mediated Intracellular Delivery of CuZn-superoxide Dismutase Protects Against Redox-Induced Apoptosis

2. Proof of concept, Scientific studiesBy glisodinadminDecember 8, 2000Leave a comment

The development of dietary delivery systems using wheat gliadin biopolymers; as a natural carrier represents a new alternative.

glisodin sod - gliadin complex
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