We investigated the potential protective effects of two antioxidant molecules: Glisodin, a gliadin combined copper-zinc superoxide dismutase SOD (Cu,Zn SOD)-rich melon extract, SOD is a known enzyme that has been best studied as a regulator of antioxidant defence, and an antioxidant agent N-acetylcysteine (NAC). Glisodin, given orally to rats fed a chow diet, as 180 U/d during 2 weeks in a preconditioning treatment, and then for 8 weeks, combined to a high fat/high fructose diet (HF/HFr), had more positive effects than NAC (100 mg/d), not only on oxidative stress parameters, but also on features of the metabolic-syndrome. DNA oxidative damages, lipid peroxidation, and fasting glycaemia were lower in rats receiving Glisodin than in those supplemented by NAC. In addition, insulin sensitivity was improved and mesenteric fat was significantly lower in rats fed the Fr/Fe diet plus Glisodin than in animals fed NAC supplementation.
These data suggest potential beneficial effects of oral Glisodin supplementation in preventing metabolic alterations related to the metabolic syndrome.