Influence of an orally effective superoxide dismutase (glisodin) on strenuous exercise induced changes of blood antioxidant enzymes and plasma lactate

Strenuous exercise abruptly increases oxygen consumption aggravating oxidative stress by generation of free radicals. In healthy individuals, the antioxidant system defends tissues against free radical attack and superoxide dismutase (SOD) is one of the major antioxidant enzymes.

 

Recently an effective oral preparation of SOD was developed and w e evaluated its influence on exercise-related change of blood antioxidants and lactate. Forty -four healthy volunteers participated in this study and a daily dose of 1500 IU oral SOD (Glisodin®) was administered to each participant for 4 weeks. Before and after the 4 week SOD treatment, they performed the same quantity of acute cycling or treadmill exercise. Shortly before and after the exercise serum total antioxidant status (TAS), erythrocytic SOD, whole blood glutathione peroxidase (GPx), serum glutathione reductase (GR), and plasma lactate (Lac) of each participant were measured. B ased on the degree of initial exercise-induced lactate increase, subjects were classified into severe exercise group (n=27) and moderate exercise group (n=17). After 4 week adminitration of oral SOD, baseline TAS and GR were significantly decreased (p<0.01) while SOD, GPx and Lac showed no significant change. In severe exercise group, significant exercise-induced increases in TAS, SOD, GR and Lac were observed before SOD treatment ( p<0.01).

 

After 4 week SOD administration, this group showed significantly decreased amount of exercise-induced increases in TAS , SOD (p<0.05) and Lac (p<0.01).

 

These results suggest that exhausting exercise is responsible for a significant increase in blood TAS, SOD, GR and Lac and a 4-week administration of the newly developed oral SOD induces a significant change in oxidative status and a significant decrease in exercise-induced lactate release.